HCID 67959446、化合物 → 8-(3-Methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine

HRID 1404980ノート

反応式

HRID 1404980 の反応式
[CH2:1]([C:3]1[C:12]2[O:11][CH:10]([CH3:13])[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][C:6]=2[S:5][CH:4]=1)[CH3:2]>C(OCC)(=O)C.Cl>[CH3:10][O:11][C:12]1[CH:3]=[C:1]([C:3]2[C:12]3[O:11][CH:10]([CH3:13])[CH2:9][NH:8][CH2:7][C:6]=3[S:5][CH:4]=2)[CH:2]=[CH:7][CH:6]=1

参加物

3

反応物 1

HCID 67959446HCID 67959446、化合物

生成物 1

HCID 679591608-(3-Methoxyphenyl)-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine収率 148.9%

試薬・触媒・溶媒 1

HCID 21866389Hydrogen chloride-ethyl acetate溶媒

実験手順

tert-Butyl 8-ethyl-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (190 mg) was stirred in 4N hydrogen chloride-ethyl acetate solution (5 mL) for 20 min. The reaction solution was concentrated under reduced pressure, and the residue was recrystallized from ethyl acetate to give 8-ethyl-2-methyl-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine 1 hydrochloride (131 mg, 88%) as colorless crystals.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-1f59d02dec654337bb47416525f9719d
出典データセット
uspto-grants-2014_12
特許番号
US08916549B2

反応ノート

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