2-Amino-4-chloro-6-methylpyrimidine → 4-Methyl-6-(3-methylphenyl)-2-pyrimidinamine
反応式
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[CH:15][CH:16]=1>>[CH3:9][C:4]1[CH:5]=[C:6]([C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:10])[CH:16]=2)[N:7]=[C:2]([NH2:1])[N:3]=1参加物
3
実験手順
The title compound is synthesized according to general procedure GP4 starting from 2.0 g (14 mmol) 2-amino-4-chloro-6-methylpyrimidine and 2.5 g (18 mmol) 3-methyl-phenyl boronic acid. Yield after extraction and re-crystallization from diethylether: 4.1 g (>100%, approximately 70% pure).
後処理
- customYield
- extractionafter extraction and re-crystallization from diethylether
出典と根拠
- ORDレコード
- ord-8c673d2a4f184d7385067374ab706f2d
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08916548B2
反応ノート
読み込み中…