Phenylboronic Acid → 3-(4-Nitrophenyl)-4-phenylpyridine
反応式
Br[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.[C:17]1(B(O)O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.CC1C=CN=CC=1C1C=CC=C2C=1C=NN2>>[N+:14]([C:11]1[CH:12]=[CH:13][C:8]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][C:2]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:9][CH:10]=1)([O-:16])=[O:15]参加物
4
実験手順
Intermediate 13B was prepared from Intermediate 13A and phenylboronic acid by the procedure described for the preparation of Intermediate 1C. The crude material was purified by silica gel chromatography (12 g ISCO column, eluting with 0 to 40% EtOAc in CH2Cl2) to yield Intermediate 13B. MS (ES): m/z=277.0 [M+H]+.
後処理
- customThe crude material was purified by silica gel chromatography (12 g ISCO column, eluting with 0 to 40% EtOAc in CH2Cl2)