{2-[(3-Fluorophenyl)methoxy]phenyl}boronic acid → HCID 66576517、化合物

HRID 1405189ノート

反応式

HRID 1405189 の反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1.[F:20][C:21]1[CH:22]=[C:23]([CH:35]=[CH:36][CH:37]=1)[CH2:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1B(O)O>>[F:20][C:21]1[CH:22]=[C:23]([CH:35]=[CH:36][CH:37]=1)[CH2:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][S:16]([CH3:19])(=[O:18])=[O:17])[CH:10]=2)[N:3]=1

参加物

3

反応物 2

HCID 16218053{2-[(3-Fluorophenyl)methoxy]phenyl}boronic acidHCID 219563434-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

生成物 1

HCID 66576517HCID 66576517、化合物

実験手順

Example 26 was prepared under similar conditions as described in the preparation of Example 1 using crude 4-chloro-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine and {2-[(3-fluorobenzyl)oxy]phenyl}boronic acid (Aldrich Chemical Company Inc.). The batch was purified by preparative HPLC.

後処理

  1. customExample 26 was prepared under similar conditions
  2. customThe batch was purified by preparative HPLC

出典と根拠

ORDレコード
ord-d206671fc88e4abaa1b56fabeae7a13b
出典データセット
uspto-grants-2014_12
特許番号
US08916557B2

反応ノート

読み込み中…