2,3-Difluorobenzyl Alcohol → 4-{2-[(2,3-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amine

HRID 1405249ノート

反応式

HRID 1405249 の反応式
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1.[F:27][C:28]1[C:35]([F:36])=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][OH:31]>>[F:27][C:28]1[C:35]([F:36])=[CH:34][CH:33]=[CH:32][C:29]=1[CH2:30][O:31][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[N:10]=1

参加物

3

反応物 2

HCID 4471532,3-Difluorobenzyl AlcoholHCID 709765244-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

生成物 1

HCID 665760524-{2-[(2,3-Difluorobenzyl)oxy]-4-fluorophenyl}-N-{3-[(methylsulfonyl)-methyl]phenyl}-1,3,5-triazin-2-amine

実験手順

Starting with 4-(2,4-difluorophenyl)-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine (70 mg; 0.184 mmol), intermediate 42.1, and 2,3-difluorobenzyl alcohol (113 mg; 0.736 mmol), example 80 was prepared analogously to the procedure for the preparation of example 42.

後処理

  1. customwas prepared analogously to the procedure for the preparation of example 42

出典と根拠

ORDレコード
ord-ea9ea69c05734fb784567f6e6e95d1b6
出典データセット
uspto-grants-2014_12
特許番号
US08916557B2

反応ノート

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