関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-Amino-3-bromopyridine | HCID 817700 | — |
| 反応物 | 4-Butoxyphenylboronic Acid | HCID 3836310 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | 3-(4-Butoxyphenyl)pyridin-2-amine | HCID 66748379 | 61.7% |
反応手順
A mixture of sodium carbonate (0.978 g), tetrakis(triphenylphosphine)palladium(0) (0.267 g), 4-butoxyphenylboronic acid (1.16 g) and 3-bromopyridin-2-amine (0.799 g,) in DME (23 mL) and water (4.6 mL) was stirred at 80° C. overnight. The mixture was added with silica gel, concentrated in vacuo, and purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (0.690 g) as a pale yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08916551B2 |
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| 出典データセット | uspto-grants-2014_12 |
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| ORD ID | ord-5388152dd37a4cf28f9e9453bbd17ddb |
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| 出典メモ | uspto-grants-2014_12 |
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