Dimethylformamide dimethyl acetal → HCID 178496147、化合物
反応式
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][CH2:12][O:13][CH3:14])[C:7]([O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][C:28]2[CH:33]=[C:32]([NH2:34])[C:31]([C:35]#[N:36])=[CH:30][C:29]=2[O:37][CH2:38][CH2:39][O:40][CH3:41])=[CH:6][C:3]=1[C:4]#[N:5].[CH3:42][N:43]([CH:45](OC)OC)[CH3:44]>CCOCC>[C:4]([C:3]1[CH:6]=[C:7]([O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][C:28]2[CH:33]=[C:32](/[N:34]=[CH:42]/[N:43]([CH3:45])[CH3:44])[C:31]([C:35]#[N:36])=[CH:30][C:29]=2[O:37][CH2:38][CH2:39][O:40][CH3:41])[C:8]([O:10][CH2:11][CH2:12][O:13][CH3:14])=[CH:9][C:2]=1/[N:1]=[CH:42]/[N:43]([CH3:45])[CH3:44])#[N:5]参加物
4
実験手順
2-Amino-5-(2-(2-(2-(2-(5-amino-4-cyano-2-(2-methoxyethoxy)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)-4-(2-methoxyethoxy)benzonitrile (0.18 g) was added to DMF-DMA (3 mL), the resulting mixture was heated to reflux overnight under N2 atmospheres. After reaction finished, the mixture was diluted with Et2O (30 mL) and solid was collected. The solid was washed with Et2O and air-dried to give (E)-N′-(2-cyano-4-(2-(2-(2-(2-(4-cyano-5-((E)-((dimethylamino)methylene)amino)-2-(2-methoxyethoxy)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)-5-(2-methoxyethoxy)phenyl)-N,N-dimethylformimidamide (0.2 g) as a yellow solid, which was used in next step directly without any purification.