4-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile → 4-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzylamine

HRID 1406330ノート

反応式

HRID 1406330 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][C:8]=2[F:15])=[C:4]([F:18])[CH:3]=1>N.[Ni]>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:10]([CH2:11][NH2:12])=[CH:9][C:8]=2[F:15])=[C:4]([F:18])[CH:3]=1

参加物

4

反応物 1

HCID 667894214-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile

生成物 1

HCID 584879074-(4-Chloro-2-fluoro-phenoxy)-3-fluoro-benzylamine収率 99%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 222Ammonia溶媒

実験手順

1.0 g (3.76 mmol) of 4-(4-chloro-2-fluoro-phenoxy)-3-fluoro-benzonitrile were hydrogenated in 30 mL methanolic ammonia solution with the addition of Raney nickel at 50° C. under a hydrogen pressure of 50 psi. Then the catalyst was filtered off and the filtrate was evaporated to dryness. The crude product thus obtained was reacted further without any further purification.

後処理

  1. filtrationThen the catalyst was filtered off
  2. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-e937f86b4fdf4fd49a4a5821587aecaa
出典データセット
uspto-grants-2014_12
特許番号
US08916589B2

反応ノート

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