Ammonia → 1-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamine

HRID 1406333ノート

反応式

HRID 1406333 の反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[N:15]O)[CH3:14])=[CH:9][CH:8]=2)=[C:4]([F:19])[CH:3]=1.N.[H][H]>CO.[Ni]>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([CH:13]([NH2:15])[CH3:14])=[CH:11][CH:12]=2)=[C:4]([F:19])[CH:3]=1

参加物

6

反応物 3

HCID 222AmmoniaHCID 866588121-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethanone-oximeHCID 178418361HCID 178418361、化合物

生成物 1

HCID 584879121-[4-(4-Chloro-2-fluoro-phenoxy)-phenyl]-ethylamine収率 89%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

2.60 g (9.3 mmol) of 1-[4-(4-chloro-2-fluoro-phenoxy)-phenyl]-ethanone-oxime were dissolved in 20 mL methanol, then combined with 30 mL 7N methanolic ammonia solution and after the addition of 0.2 g Raney nickel hydrogenated at ambient temperature and 50 psi hydrogen pressure. Then the catalyst was filtered off and the filtrate was evaporated down. The crude product thus obtained was reacted further without any further purification.

後処理

  1. customhydrogenated at ambient temperature
  2. filtrationThen the catalyst was filtered off
  3. customthe filtrate was evaporated down

出典と根拠

ORDレコード
ord-3d8902e9953a4ddfa68ff2712a45a7f9
出典データセット
uspto-grants-2014_12
特許番号
US08916589B2

反応ノート

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