4-Methoxyphenol → 3-Fluoro-4-(4-methoxy-phenoxy)-benzaldehyde
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1F)[CH:14]=[O:15]>CC(N(C)C)=O>[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[O:9][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[CH:14]=[O:15]参加物
4
反応条件
- 温度
- 110 °C
実験手順
4.9 g (40 mmol) of 4-methoxy-phenol and 4.4 ml (40 mmol) of 3,4-difluorobenzaldehyde were dissolved in 40 ml DMA and stirred in a microwave (CEM Explorer) for 15 minutes at 110° C., then filtered through basic Alox, washed with DMF and concentrated by rotary evaporation. The residue was separated through a KG column with a gradient (cyclohexane+10-25% ethyl acetate) and concentrated by rotary evaporation.
後処理
- filtrationfiltered through basic Alox
- washwashed with DMF
- concentrationconcentrated by rotary evaporation
- customThe residue was separated through a KG column with a gradient (cyclohexane+10-25% ethyl acetate)
- concentrationconcentrated by rotary evaporation
出典と根拠
- ORDレコード
- ord-6d694ab1a44541eebdc880fadf9c7f6a
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08916589B2
反応ノート
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