Ammonia → HCID 43189234、化合物

HRID 1406342

反応式

HRID 1406342 の反応式
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[H][H].[NH3:21]>[Ni]>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([CH:14]([NH2:21])[CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 27772531-(4-(4-Methoxyphenoxy)phenyl)ethan-1-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 43189234HCID 43189234、化合物

試薬・触媒・溶媒 1

HCID 935Nickel触媒2 回

反応条件

温度
50 °C

実験手順

78 mg (0.32 mmol) of 1-[4-(4-methoxy-phenoxy)-phenyl]-ethanone were dissolved in 10 ml of 7M methanolic ammonia and combined with 50 mg of Raney nickel. The mixture was shaken for 6 h at 50° C. and 3 bar hydrogen pressure. Raney nickel was added twice more and hydrogenation was continued for 2 h and 6 h under the same conditions. The catalyst was removed by suction filtering and the residue was evaporated down.

後処理

  1. waithydrogenation was continued for 2 h and 6 h under the same conditions
  2. customThe catalyst was removed by suction
  3. filtrationfiltering
  4. customthe residue was evaporated down

出典と根拠

ORDレコード
ord-e1c080c3ddbd4ac1939198ac2b945bd3
出典データセット
uspto-grants-2014_12
特許番号
US08916589B2

関連ノート

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