Hydroxylamine → HCID 86658821、化合物
反応式
[F:1][CH:2]([F:20])[O:3][C:4]1[CH:19]=[CH:18][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=O)[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.[NH2:21][OH:22]>C(O)C>[F:1][CH:2]([F:20])[O:3][C:4]1[CH:19]=[CH:18][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:21][OH:22])[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1参加物
4
実験手順
A mixture of 1.37 g (4.92 mmol) of 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone and 1.16 mL hydroxylamine solution (50% in water) in 5 mL ethanol was refluxed for 3 hours. Then the mixture was concentrated and evaporated down several times with ethanol, and the residue was purified by chromatography (silica gel column, petroleum ether/ethyl acetate).
後処理
- temperaturewas refluxed for 3 hours
- concentrationThen the mixture was concentrated
- customevaporated down several times with ethanol
- customthe residue was purified by chromatography (silica gel column, petroleum ether/ethyl acetate)
出典と根拠
- ORDレコード
- ord-94b9620ebbcc4851973e0d1568396df2
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08916589B2
反応ノート
読み込み中…