HCID 86658821、化合物 → 1-[4-(4-Difluoromethoxy-phenoxy)-phenyl]-ethylamine
反応式
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:20]=[CH:19][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=[N:17]O)[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.[H][H]>N.[Ni]>[F:1][CH:2]([F:21])[O:3][C:4]1[CH:20]=[CH:19][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]([NH2:17])[CH3:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1参加物
5
実験手順
1.35 g (4.60 mmol) of 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone-oxime were dissolved in 50 ml of 7M methanolic ammonia, then combined with 100 mg Raney nickel. The mixture was shaken overnight at RT and 50 psi hydrogen pressure. The catalyst was removed by suction filtering and the filtrate was evaporated down.
後処理
- customThe catalyst was removed by suction
- filtrationfiltering
- customthe filtrate was evaporated down
出典と根拠
- ORDレコード
- ord-7e8496d483644c6e97c87d12ee6f25f7
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08916589B2
反応ノート
読み込み中…