Ethanol → Ethyl 4-amino-2-fluoro-5-nitrobenzoate
反応式
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:14])[CH:3]=1.[CH2:15]([OH:17])[CH3:16]>>[CH2:15]([O:17][C:6](=[O:7])[C:5]1[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:2]([NH2:1])=[CH:3][C:4]=1[F:14])[CH3:16]参加物
3
実験手順
A solution of the product obtained at 149e (1.4 g, 6.4 mmol) in 50 mL ethanol was heated to reflux for 2 h. The mixture was filtered and the filtrate concentrated i.vac. The residue is reacted without any further purification. Yield: 89%.
後処理
- temperaturewas heated
- temperatureto reflux for 2 h
- filtrationThe mixture was filtered
- concentrationthe filtrate concentrated i.vac
- customThe residue is reacted without any further purification
出典と根拠
- ORDレコード
- ord-bb09c702cf3849beb02397cf6bbc8c08
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08916599B2
反応ノート
読み込み中…