Water → 4-(4-n-Propylphenyl)phenol

HRID 1406837ノート

反応式

HRID 1406837 の反応式
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].B(Br)(Br)Br.O>ClCCl>[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)=[CH:6][CH:5]=1)[CH2:2][CH3:3]

参加物

5

反応物 3

HCID 962WaterHCID 25134Boron tribromideHCID 220687594-Methoxy-4′-propylbiphenyl

生成物 1

HCID 136276804-(4-n-Propylphenyl)phenol収率 78.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Then, 21.60 g of 4-(4-propylphenyl)anisole was dissolved in 45 mL of dichloromethane, and the resultant solution was cooled with ice. Then, 35.79 g of boron tribromide was added to the solution at such a rate that the inside temperature did not exceed 10° C., followed by stirring at room temperature for 1 hour. Water was added to separate the mixture into layers, and an organic layer was washed with a saturated aqueous sodium bicarbonate solution and saturated brine and dried by adding sodium sulfate. Then, the solvent was distilled off under reduced pressure, and the residue was recrystallized from ethanol to yield 15.91 g of 4-(4-propylphenyl)phenol.

後処理

  1. customdid not exceed 10° C.
  2. customto separate the mixture into layers
  3. washan organic layer was washed with a saturated aqueous sodium bicarbonate solution and saturated brine
  4. customdried
  5. additionby adding sodium sulfate
  6. distillationThen, the solvent was distilled off under reduced pressure
  7. customthe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-a323e2b0fd784a9cabe0b16f2f690916
出典データセット
uspto-grants-2014_12
特許番号
US08916718B2

反応ノート

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