n-(3-(4-(1h-Indazol-5-ylamino)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-2-yl)phenyl)butyramide di-hydrochloride salt → N-(3-(4-(1H-Indazol-5-ylamino)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-2-yl)phenyl)butyramide

HRID 1407027ノート

反応式

HRID 1407027 の反応式
Cl.Cl.[NH:3]1[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH2:24][CH2:25][N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)[CH:21]=4)[N:16]=[C:15]([C:31]4[CH:32]=[C:33]([NH:37][C:38](=[O:42])[CH2:39][CH2:40][CH3:41])[CH:34]=[CH:35][CH:36]=4)[N:14]=3)=[CH:9][CH:10]=2)[CH:5]=[N:4]1>Cl>[NH:3]1[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH2:24][CH2:25][N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)[CH:21]=4)[N:16]=[C:15]([C:31]4[CH:32]=[C:33]([NH:37][C:38](=[O:42])[CH2:39][CH2:40][CH3:41])[CH:34]=[CH:35][CH:36]=4)[N:14]=3)=[CH:9][CH:10]=2)[CH:5]=[N:4]1

参加物

3

反応物 1

HCID 66826580n-(3-(4-(1h-Indazol-5-ylamino)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-2-yl)phenyl)butyramide di-hydrochloride salt

生成物 1

HCID 25012088N-(3-(4-(1H-Indazol-5-ylamino)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-2-yl)phenyl)butyramide

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

The purified solid was taken up in HCl (4M in 1,4 dioxane, 2 mL) and stirred at RT for 2 h. The volatiles were removed in vacuo to give N-(3-(4-(1H-indazol-5-ylamino)-6-(2-(pyrrolidin-1-yl)ethoxy)quinazolin-2-yl)phenyl)butyramide di-hydrochloride salt (0.120 g, 0.198 mmol, 70% over two steps). MS 536 (M+1). HPLC retention time 4.61 mins.

後処理

  1. customThe volatiles were removed in vacuo

出典と根拠

ORDレコード
ord-fa48718cb6ba498cae87876437375286
出典データセット
uspto-grants-2014_12
特許番号
US08916576B2

反応ノート

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