Acetic Anhydride → N-[(5-bromo-2-chlorophenyl)methyl]acetamide

HRID 1408415ノート

反応式

HRID 1408415 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:10])=[C:6]([CH2:8][NH2:9])[CH:7]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:10])=[C:6]([CH2:8][NH:9][C:11](=[O:13])[CH3:12])[CH:7]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 43378979(5-Bromo-2-chlorophenyl)methanamine2 回

生成物 1

HCID 67151142N-[(5-bromo-2-chlorophenyl)methyl]acetamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

To a solution of 5-bromo-2-chlorobenzenemethanamine (i.e. the product of Step A) (600 mg, 2.72 mmol) in toluene (10 mL) at 0° C. was added acetic anhydride (0.55 mL, 5.45 mmol). The reaction mixture was stirred at 100° C. for 3 h. The reaction mixture was then extracted with ethyl acetate (3×), and the organic layers were combined, washed with water and brine and dried (Na2SO4). The solvent was evaporated to provide the title product (600 mg).

後処理

  1. extractionThe reaction mixture was then extracted with ethyl acetate (3×)
  2. washwashed with water and brine
  3. dry with materialdried (Na2SO4)
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-5664014ba3a342219a3482f8bc3cb41a
出典データセット
uspto-grants-2014_12
特許番号
US08921360B2

反応ノート

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