Dimethylformamide dimethyl acetal → N-[[2-chloro-5-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-phenyl]methyl]acetamide
反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([Cl:15])=[C:8]([CH2:10][NH:11][C:12](=[O:14])[CH3:13])[CH:9]=1)(=[O:3])[CH3:2].CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>C1(C)C=CC=CC=1>[Cl:15][C:7]1[CH:6]=[CH:5][C:4]([C:1](=[O:3])[CH:2]=[CH:18][N:19]([CH3:21])[CH3:20])=[CH:9][C:8]=1[CH2:10][NH:11][C:12](=[O:14])[CH3:13]参加物
4
反応条件
- 温度
- 105 °C
実験手順
A mixture of N-[(5-acetyl-2-chlorophenyl)methyl]acetamide (13.0 g, 57.8 mmol; prepared according to a procedure described in EP 1586552-A1) and N,N-dimethylformamide dimethyl acetal (13.8 g, 115.8 mmol) in toluene (130 mL) was heated at 105° C. overnight. The reaction mixture was then concentrated, and the resulting solid was washed with diethyl ether and n-pentane to yield the title product as a solid (10.0 g).