Morpholine → 4-(5-Chlorothiazolo[4,5-d]pyrimidin-7-yl)morpholine
反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[N:8][C:6]=2[N:7]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CO>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][CH:9]=[N:8][C:6]=2[N:7]=1参加物
4
実験手順
A mixture of 5,7-dichlorothiazolo[4,5-d]pyrimidine (1.0 eq.), morpholine (2.2 eq.) and MeOH was stirred at room temperature for 1 h. The reaction mixture was then filtered, washed with water and MeOH, to yield 4-(5-chlorothiazolo[4,5-d]pyrimidin-7-yl)morpholine as a white solid (100%).
後処理
- filtrationThe reaction mixture was then filtered
- washwashed with water and MeOH
出典と根拠
- ORDレコード
- ord-adcd960ccfb246bf94ef778be6da7fbe
- 出典データセット
- uspto-grants-2014_12
- 特許番号
- US08921361B2
反応ノート
読み込み中…