2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyridin-2-yl]-phenyl}-pyrimidin-2-ylamine

反応式

[Br:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([C:21]([F:22])([F:23])[F:24])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]3)[cH:13]2)[cH:5][cH:6][cH:7]1.[NH2:25][c:26]1[n:27][cH:28][c:29]([B:32]2[O:33][C:34]([CH3:35])([CH3:36])[C:37]([CH3:38])([CH3:39])[O:40]2)[cH:30][n:31]1>>[c:2]1(-[c:29]2[cH:28][n:27][c:26]([NH2:25])[n:31][cH:30]2)[cH:3][c:4](-[c:8]2[n:9][c:10]([C:21]([F:22])([F:23])[F:24])[cH:11][c:12](-[c:14]3[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]3)[cH:13]2)[cH:5][cH:6][cH:7]1

参加物

反応物 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

HCID 574687962-(3-Bromo-phenyl)-4-(4-chloro-phenyl)-6-trifluoromethyl-pyridine

生成物 1

HCID 602094555-{3-[4-(4-Chloro-phenyl)-6-trifluoromethyl-pyridin-2-yl]-phenyl}-pyrimidin-2-ylamine

出典と根拠

ORDレコード: ord-90ca9db99bb34ad1afb1f7af1f899457
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…