1,2-Dichloroethane → HCID 178513561、化合物

HRID 1409117ノート

反応式

HRID 1409117 の反応式
Br[C:2]1[C:7](Cl)=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.C(Cl)CCl.[CH:16]1[CH:17]=C[C:19]2[N:24](O)N=[N:22][C:20]=2[CH:21]=1.CN(C=[O:30])C>>[N:9]1[CH:10]=[CH:11][C:3]2[C:4]=1[NH:5][CH:6]=[CH:7][C:2]=2[C:16]1[CH:21]=[C:20]([C:19]([NH2:24])=[O:30])[NH:22][CH:17]=1

参加物

5

反応物 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 178513561HCID 178513561、化合物

実験手順

To a vial with Compound D′ (0.1 mmol) in DMF (1 mL), EDC (2 equivalent, 0.2 mmol) and HOBt (0.5 equivalent, 0.05 mmol) were added and the reaction mixture was stirred at room temperature for half an hour, amine (1.2 equivalent, 0.12 mmol) was added and the reaction mixture was stirred at room temperature for 2-3 hour. Reverse phase HPLC was used to purify the final compound.

後処理

  1. stirringthe reaction mixture was stirred at room temperature for 2-3 hour
  2. customto purify the final compound

出典と根拠

ORDレコード
ord-f2310ed1b88740c2b2f637a35f217648
出典データセット
uspto-grants-2014_12
特許番号
US08921376B2

反応ノート

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