1-Bromo-2-methyl-1-propene → Methyl 1-(2-methylprop-1-enyl)-1H-pyrazole-3-carboxylate

HRID 1409384ノート

反応式

HRID 1409384 の反応式
[NH:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8][CH3:9])=[O:7])=[N:2]1.Br[CH:11]=[C:12]([CH3:14])[CH3:13]>>[CH3:13][C:12]([CH3:14])=[CH:11][N:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8][CH3:9])=[O:7])=[N:2]1

参加物

3

反応物 2

HCID 985601-Bromo-2-methyl-1-propeneHCID 178498454HCID 178498454、化合物

生成物 1

HCID 86714646Methyl 1-(2-methylprop-1-enyl)-1H-pyrazole-3-carboxylate

実験手順

The title compound was prepared using the procedure described in Example 17(a) starting from methyl 1H-pyrazole-3-carboxylate (8 g, 63.4 mmol) and 1-bromo-2-methyl propene (12.7 g, 95.2 mmol). The product was purified with flash chromatography. Yield 2.4 g. 1H-NMR (400 MHz; CDCl3): δ 1.81 (d, 3H), 1.87 (d, 3H), 3.93 (s, 3H), 6.70 (d, 1H), 6.87 (d, 1H), 7.47 (d, 1H).

後処理

  1. customThe product was purified with flash chromatography

出典と根拠

ORDレコード
ord-6b4e8f7c78034896a946de2e0bd9aa1c
出典データセット
uspto-grants-2014_12
特許番号
US08921378B2

反応ノート

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