化工社化工社 化学情報印刷レポート · 研究参考用
1,2-Dichloroethane → 2-chloro-N-(isoquinolin-6-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dichloroethane | HCID 11 | — |
| 反応物 | Chloroacetic Acid | HCID 300 | — |
| 反応物 | 6-Aminoisoquinoline | HCID 588991 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-chloro-N-(isoquinolin-6-yl)acetamide | HCID 24999501 | — |
反応手順
To chloroacetic acid in DMF was added EDC, DMAP and 6-aminoisoquinoline. This mixture was stirred for 4 hours. The reaction was washed with NaHCO3(sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Column chromatography (SiO2, 5% MeOH/CH2Cl2) gave 2-chloro-N-(isoquinolin-6-yl)acetamide (E1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08921392B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-aa7cb571d2084709a5a28babe1feb6b6 |
| 出典メモ | uspto-grants-2014_12 |