化工社化工社 化学情報印刷レポート · 研究参考用
2-Chloro-5-ethylpyrimidine → (3S,4R)-N-cyclopropyl-1-(5-ethylpyrimidin-2-yl)-3-fluoropiperidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloro-5-ethylpyrimidine | HCID 3572763 | — |
| 反応物 | tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate | HCID 68290240 | — |
| 生成物 | (3S,4R)-N-cyclopropyl-1-(5-ethylpyrimidin-2-yl)-3-fluoropiperidin-4-amine | HCID 68290585 | — |
反応手順
The title compound is prepared from tert-butyl N-cyclopropyl-N-[(3S,4R)-3-fluoropiperidin-4-yl]carbamate and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described for Intermediate 87. LC (method 20): tR=1.80 min; Mass spectrum (APCI): m/z=265 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08921398B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-96d6563191d641cab620d8577d9ce3ac |
| 出典メモ | uspto-grants-2014_12 |