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2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid (1-cyano-piperidin-4-yl)-cyclopropyl-amide → 2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-ethyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid (1-cyano-piperidin-4-yl)-cyclopropyl-amide | HCID 86686164 | — |
| 反応物 | HCID 178458070 | HCID 178458070 | — |
| 生成物 | 2-(4-Cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid cyclopropyl-[1-(3-ethyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-amide | HCID 86686163 | — |
反応手順
The title compound is prepared from 2-(4-cyanomethyl-phenyl)-pyrimidine-5-carboxylic acid (1-cyano-piperidin-4-yl)-cyclopropyl-amide and N-hydroxy-propionamidine following a procedure analogous to that described in Example 6. LC (method 3): tR=1.86 min; Mass spectrum (ESI+): m/z=458 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08921398B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-0fb86acdfc004561a166636b0563c95d |
| 出典メモ | uspto-grants-2014_12 |