Hydrochloric Acid → HCID 178478713、化合物

HRID 1409861

反応式

HRID 1409861 の反応式
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH:17]2[C:22]2[CH:23]=[C:24]3[CH:28]=[CH:27][CH:26]=[C:25]3[O:29][CH:30]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:32].C(OCC)C>ClCCl>[ClH:32].[ClH:32].[O:29]1[C:25]2=[CH:26][CH:27]=[CH:28][C:24]2=[CH:23][C:22]([CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][N:16]2[CH2:15][CH2:14][C@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)=[CH:30]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178453896HCID 178453896、化合物

生成物 1

HCID 178478713HCID 178478713、化合物収率 88%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of trans-{4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester (2.3 g, 5.39 mmol) in dichloromethane (40 ml) was added at room temperature hydrochloric acid solution (4M in dioxane, 20.2 ml, 80.9 mmol) and the mixture was allowed to stir for 2 h, diethyl ether (50 ml) was added and the mixture was allowed to stir for 30 min at room temperature. The precipitate was collected by filtration, washed with diethyl ether and dried to yield the title compound as a white solid (1.89 g, 88%), MS (ISP) m/z=327.4 [(M+H)−], mp 339° C.

後処理

  1. stirringto stir for 30 min at room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with diethyl ether
  4. customdried

出典と根拠

ORDレコード
ord-8e1e814fe8644ea5ab77d55806ebeef6
出典データセット
uspto-grants-2014_12
特許番号
US08921397B2

関連ノート

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