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2-(Methoxymethyl)-1-(3-nitrophenyl)pyrrolidine → 3-(2-(Methoxymethyl)pyrrolidin-1-yl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Methoxymethyl)-1-(3-nitrophenyl)pyrrolidine | HCID 68379240 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-(2-(Methoxymethyl)pyrrolidin-1-yl)aniline | HCID 68379331 | 97% |
反応手順
The mixture of 2-(methoxymethyl)-1-(3-nitrophenyl)pyrrolidine (200 mg, 0.85 mmol), Pd/C (50 mg, 10%) in 50 mL of MeOH was stirred at room temperature for 18 hours under H2 atmosphere. Pd/C was filtrated off and the filtrate was concentrated under reduce pressure to give crude 3-(2-(methoxymethyl)pyrrolidin-1-yl)aniline (170 mg) as an oil. LC-MS: 207 [M+H]+, tR=1.15 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08921383B2 |
| 出典データセット | uspto-grants-2014_12 |
| ORD ID | ord-522aa5c99bb349a4b7ff8428aab15cf4 |
| 出典メモ | uspto-grants-2014_12 |