Diisopropylcarbodiimide → HCID 46871734、化合物
反応式
CC(N=C=NC(C)C)C.[C:10]([NH:13][CH:14]([C:16]1[CH:17]=[CH:18][C:19]([Cl:44])=[C:20]([NH:22][C:23](=S)[NH:24][C:25]2[CH:26]=[C:27]([CH:38]=[CH:39][C:40]=2[NH:41][CH3:42])[C:28]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([Br:37])=[CH:33][CH:32]=2)=[O:29])[CH:21]=1)[CH3:15])(=[O:12])[CH3:11]>CN(C=O)C>[C:10]([NH:13][CH:14]([C:16]1[CH:17]=[CH:18][C:19]([Cl:44])=[C:20]([NH:22][C:23]2[N:41]([CH3:42])[C:40]3[CH:39]=[CH:38][C:27]([C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([Br:37])=[CH:33][CH:32]=4)=[O:29])=[CH:26][C:25]=3[N:24]=2)[CH:21]=1)[CH3:15])(=[O:12])[CH3:11]参加物
4
反応条件
- 温度
- 80 °C
実験手順
N,N-Diisopropylcarbodiimide (46 L, 0.2 mmol) was added to 3-{3-[5-(1-acet-amidoethyl)-2-chlorophenyl]thioureido}-N-(4-bromophenyl)-4-(methylamino)benzamide (130 mg, 0.2 mmol) in DMF (2 mL) at rt. The mixture was stirred at 80° C. for 2 h, cooled and concentrated. The residue was purified by chromatography to give the title compound.