3,4,5-Trifluorocinnamic acid → HCID 178501620、化合物

HRID 1410541

反応式

HRID 1410541 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][CH:13]([NH:16][CH:17]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[C:18]([O:20][CH3:21])=[O:19])[CH2:12][CH2:11]2)=[CH:2]1.[F:28][C:29]1[CH:30]=[C:31]([CH:37]=[C:38]([F:41])[C:39]=1[F:40])/[CH:32]=[CH:33]/[C:34](O)=[O:35]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C@H:10]2[CH2:15][CH2:14][C@H:13]([NH:16][CH:17]([CH:22]3[CH2:23][CH2:24][N:25]([C:34](=[O:35])/[CH:33]=[CH:32]/[C:31]4[CH:30]=[C:29]([F:28])[C:39]([F:40])=[C:38]([F:41])[CH:37]=4)[CH2:26][CH2:27]3)[C:18]([O:20][CH3:21])=[O:19])[CH2:12][CH2:11]2)=[CH:2]1

参加物

3

反応物 2

HCID 57087793,4,5-Trifluorocinnamic acidHCID 67774409Methyl 2-((4-(1H-indol-3-yl)cyclohexyl)amino)-2-(piperidin-4-yl)acetate

生成物 1

HCID 178501620HCID 178501620、化合物

実験手順

The title compound was prepared from methyl 2-((4-(1H-indol-3-yl)cyclohexyl)amino)-2-(piperidin-4-yl)acetate (from Example 24, step A) and trans-3,4,5-trifluorocinnamic acid, by the method of Example 1, step K, and the mixture of product diastereomers was separated by flash chromatography giving a pale yellow solid for the more polar cyclohexyl diastereomer (trans, Example 49a), a tan solid for the less polar cyclohexyl diastereomer (cis, Example 49b). Mass spectrum (LCMS, APCI pos.) calcd. for C31H35F2N3O3: 536 (M+H). Found: 536.

後処理

  1. additionthe mixture of product diastereomers
  2. customwas separated by flash chromatography

出典と根拠

ORDレコード
ord-06a76240f05b467a956a7309a7adc1c9
出典データセット
uspto-grants-2014_12
特許番号
US08921559B2

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