Acetoxyacetyl chloride → 5-(3-(azetidin-1-yl)-3-oxopropyl)-1'-(2-hydroxyacetyl)-N-(5-methoxythiazol-2-yl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

反応式

C(O[C:4](=[O:36])[CH2:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:15]3([CH2:19][CH2:18][N:17]([C:20]([O:22]C(C)(C)C)=O)[CH2:16]3)[CH2:14][N:13]([C:27](OCC[Si](C)(C)C)=[O:28])[C:10]2=[CH:11][CH:12]=1)C.[NH2:37][C:38]1[S:39][C:40]([O:43][CH3:44])=[CH:41][N:42]=1.C(OC[C:50](Cl)=[O:51])(=O)C.Cl.[NH:54]1[CH2:57][CH2:56][CH2:55]1>>[N:54]1([C:4](=[O:36])[CH2:5][CH2:6][C:7]2[CH:8]=[C:9]3[C:15]4([CH2:19][CH2:18][N:17]([C:20](=[O:22])[CH2:50][OH:51])[CH2:16]4)[CH2:14][N:13]([C:27]([NH:37][C:38]4[S:39][C:40]([O:43][CH3:44])=[CH:41][N:42]=4)=[O:28])[C:10]3=[CH:11][CH:12]=2)[CH2:57][CH2:56][CH2:55]1