4-Bromo-2-chloro-5-(trifluoromethyl)aniline → N-(4-bromo-2-chloro-5-trifluoromethyl-phenyl)-6-fluoro-nicotinamide

HRID 1411361ノート

反応式

HRID 1411361 の反応式
[NH2:1][C:2]1[C:3]([Cl:13])=[CH:4][C:5]([Br:12])=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](Cl)=[O:22])=[CH:17][N:16]=1>C(Cl)Cl.CC(N(C)C)=O>[Br:12][C:5]1[C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]([NH:1][C:21](=[O:22])[C:18]2[CH:19]=[CH:20][C:15]([F:14])=[N:16][CH:17]=2)=[C:3]([Cl:13])[CH:4]=1

参加物

5

反応物 2

HCID 140993984-Bromo-2-chloro-5-(trifluoromethyl)anilineHCID 146236022-Fluoropyridine-5-carbonyl chloride

生成物 1

HCID 87422108N-(4-bromo-2-chloro-5-trifluoromethyl-phenyl)-6-fluoro-nicotinamide

試薬・触媒・溶媒 2

HCID 31374Dimethylacetamide触媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 5-amino-2-bromo-4-chlorobenzotrifluoride (466 mg, 1.70 mmol) dissolved in DCM (1 mL) was slowly added a solution of 2-fluoropyridine-5-carbonyl chloride (270 mg, 1.70 mmol) in DCM (1 mL). A few drops of DMA were added and the reaction mixture was concentrated to form N-(4-bromo-2-chloro-5-trifluoromethyl-phenyl)-6-fluoro-nicotinamide as a purple solid.

後処理

  1. concentrationthe reaction mixture was concentrated

出典と根拠

ORDレコード
ord-d5a899937165488fa0bbdb4f7a2a48c5
出典データセット
uspto-grants-2014_12
特許番号
US08921372B2

反応ノート

読み込み中…