Acetic Acid → 5-(Methylsulfonyl)-2-nitropyridine

反応式

[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[N:7][CH:8]=1.OO.[OH2:14].C(O)(=[O:17])C>>[CH3:1][S:2]([C:3]1[CH:4]=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[N:7][CH:8]=1)(=[O:17])=[O:14]

参加物

反応物 4

HCID 176Acetic Acid

HCID 784Hydrogen Peroxide

HCID 962Water

HCID 220361825-(Methylthio)-2-nitropyridine

生成物 1

HCID 203555045-(Methylsulfonyl)-2-nitropyridine収率 86%

反応条件

温度: 25 °C

実験手順

To a mixture of 117a (260 mg, 0.5 mmol) in acetic acid (15 mL) was added H2O2 (aq. 30%) (7.5 mL) and the reaction mixture was stirred overnight at 25° C. The reaction solution was poured into water and extracted with EtOAC and concentrated to a pale yellow liquid, purified by silica gel with (EtOAC/PE:1:3) to give 117b (2 g, 86%). MS: [M+H]+ 203.