Ammonia → 8-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid

HRID 1413167ノート

反応式

HRID 1413167 の反応式
[NH3:1].[CH3:2][O:3][C:4]1[C:9]2[O:10][CH2:11][CH2:12][O:13][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][C:5]=1[S:17](Cl)(=[O:19])=[O:18]>O>[CH3:2][O:3][C:4]1[C:9]2[O:10][CH2:11][CH2:12][O:13][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][C:5]=1[S:17](=[O:19])(=[O:18])[NH2:1]

参加物

4

反応物 2

HCID 222AmmoniaHCID 205447488-Methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid

生成物 1

HCID 205446908-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid収率 82%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

300 g of 34% ammonia were introduced into a balloon flask provided with an agitator and a thermometer and then 159 g of 8-methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid were added in portions, the temperature being maintained at from 0°-5° C. The mixture was agitated and then the precipitate was dissolved in water. The solution was filtered and treated with 280 cm3 of concentrated hydrochloric acid. The precipitate was dried off, washed and dried. 118 g of 8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 247°-248° C.; yield: 82%).

後処理

  1. customprovided with an agitator
  2. temperaturethe temperature being maintained at from 0°-5° C
  3. filtrationThe solution was filtered
  4. additiontreated with 280 cm3 of concentrated hydrochloric acid
  5. customThe precipitate was dried off
  6. washwashed
  7. customdried

出典と根拠

ORDレコード
ord-bcb23e05cc7a4c4e9defcb61d9f5df00
出典データセット
uspto-grants-1981_02
特許番号
US04248885

反応ノート

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