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Potassium Carbonate → 2-Cyclopentyl-6,7-dichloro-2-methyl-5-trifluoromethylsulfonyloxy-1-indanone

HRID 1413234
ノート
印刷プレビュー

反応式

HRID 1413234 の反応式
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH:14]3[CH2:18][CH2:17][CH2:16][CH2:15]3)([CH3:13])[C:8]2=[O:12])=[CH:4][C:3]=1[OH:19].C(=O)([O-])[O-].[K+].[K+].[F:26][C:27]([F:33])([F:32])[S:28](Cl)(=[O:30])=[O:29]>CC(C)=O>[CH:14]1([C:7]2([CH3:13])[CH2:6][C:5]3[C:9](=[C:10]([Cl:11])[C:2]([Cl:1])=[C:3]([O:19][S:28]([C:27]([F:33])([F:32])[F:26])(=[O:30])=[O:29])[CH:4]=3)[C:8]2=[O:12])[CH2:18][CH2:17][CH2:16][CH2:15]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 79000Trifluoromethanesulfonyl chlorideHCID 123955886,7-Dichloro-2-cyclopentyl-5-hydroxy-2-methylindan-1-one

生成物 1

HCID 125402562-Cyclopentyl-6,7-dichloro-2-methyl-5-trifluoromethylsulfonyloxy-1-indanone

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 6,7-dichloro-2-cyclopentyl-5-hydroxy-2-methyl-1-indanone (20.93 g., 0.07 mole), anhydrous potassium carbonate (25.99 g., 0.188 mole) and dry acetone (350 ml) are stirred at room temperature and treated with trifluoromethane sulfonyl chloride (12.70 g., 0.0754 mmole) in portions. Reaction is complete in about 15 minutes after the completion of the addition. The mixture is filtered and evaporated to dryness. The residue is dissolved in methylene chloride, the solution dried (MgSO4) and evaporated under vacuum to an oil giving 28.45 g. (94%),

後処理

  1. customReaction
  2. additionafter the completion of the addition
  3. filtrationThe mixture is filtered
  4. customevaporated to dryness
  5. dissolutionThe residue is dissolved in methylene chloride
  6. dry with materialthe solution dried (MgSO4)
  7. customevaporated under vacuum to an oil
  8. customgiving 28.45 g

出典と根拠

ORDレコード
ord-2ccae35062f5413eba9527c665b3537e
出典データセット
uspto-grants-1981_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04249021

反応ノート

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