Water → p-Chlorophenyl-5-methoxymethyl oxazolidine

HRID 1413321ノート

反応式

HRID 1413321 の反応式
[NH2:1][CH2:2][CH:3]([OH:7])[CH2:4][O:5][CH3:6].[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1.O>C1C=CC=CC=1>[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]2[NH:1][CH2:2][CH:3]([CH2:4][O:5][CH3:6])[O:7]2)=[CH:11][CH:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 77264-ChlorobenzaldehydeHCID 1245101-Amino-3-methoxypropan-2-ol

生成物 1

HCID 20291464p-Chlorophenyl-5-methoxymethyl oxazolidine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Twelve and six tenths (12.6) grams of 1-amino-3-methoxy-2-propanol and 16.9 grams of p-chlorobenzaldehyde were combined in 150 milliliters of benzene and heated to reflux under a modified Dean-Stark apparatus until about 2.5 milliliters of water were azeotropically removed. An additional 50 milliliters of benzene was distilled over and the mixture was cooled to room temperature and the volume was adjusted to 109.2 milliliters, so that 4 milliliters=1 gram of intermediate. Aliquots of this solution were used in subsequent reactions.

後処理

  1. temperatureheated
  2. customwere azeotropically removed
  3. distillationAn additional 50 milliliters of benzene was distilled over and the mixture

出典と根拠

ORDレコード
ord-35d95240b84540b8ac36cee8bc7d2717
出典データセット
uspto-grants-1981_02
特許番号
US04249931

反応ノート

読み込み中…