Hydrochloric Acid → 2-(Cyclopropylamino)acetic acid hydrochloride
反応式
[CH:1]1([NH:4][CH2:5][C:6]([O:8]CC)=[O:7])[CH2:3][CH2:2]1.[ClH:11]>O>[ClH:11].[CH:1]1([NH:4][CH2:5][C:6]([OH:8])=[O:7])[CH2:3][CH2:2]1参加物
4
実験手順
Ethyl cyclopropylaminoacetate was stirred in a mixture of concentrated hydrochloric acid and water until the reaction had subsided. The mixture was then heated to reflux for 2 hours. The resulting solution was evaporated to give a white solid which was triturated with acetone and recrystallised from methanol/ethyl acetate to give cyclopropylaminoacetic acid hydrochloride of melting point 189°-191° C. (decomposition).
後処理
- temperatureThe mixture was then heated
- temperatureto reflux for 2 hours
- customThe resulting solution was evaporated
- customto give a white solid which
- customwas triturated with acetone
- customrecrystallised from methanol/ethyl acetate
出典と根拠
- ORDレコード
- ord-a8b5b874a0d840b3935fdf5af68ec143
- 出典データセット
- uspto-grants-1981_02
- 特許番号
- US04250085
反応ノート
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