Phosphorus pentachloride → HCID 12901645、化合物

HRID 1413438ノート

反応式

HRID 1413438 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([OH:12])=O)=[CH:4][N:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:14]>C(OCC)C>[ClH:14].[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([Cl:14])=[O:12])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 24819Phosphorus pentachlorideHCID 128289592-Amino-4-methoxypyrimidine-5-carboxylic acid

生成物 1

HCID 12901645HCID 12901645、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To 16.9 g of 2-amino 4-methoxy 5-pyrimidinyl carboxylic acid prepared in stage 2, in suspension in 300 ml of anhydrous ethyl ether, were added at 0° C., 20.8 g of phosphorous pentachloride while stirring. After returning to room temperature for 3 hours, the precipitate was separated by filtration, rinsed several times with 50 ml of absolute ethyl ether. The hydrochloride of the 2-amino 4-methoxy 5-chlorocarbonyl pyrimidine thus obtained was used in the raw state in the following stage.

後処理

  1. customthe precipitate was separated by filtration
  2. washrinsed several times with 50 ml of absolute ethyl ether

出典と根拠

ORDレコード
ord-e5e9dcf3a4c2432699fbb661ca6a4b19
出典データセット
uspto-grants-1981_02
特許番号
US04250178

反応ノート

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