Butyric acid, 4-(p-chloro-N-2,6-xylylbenzamido)- → ethyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-(2,6-dimethylanilino)butyrate

HRID 1413582

反応式

HRID 1413582 の反応式
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20](O)=[O:21])[C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])=[O:7])=[CH:4][CH:3]=1.[CH3:25][C:26]1[CH:40]=[CH:39][CH:38]=[C:37]([CH3:41])[C:27]=1[NH:28][CH2:29][CH2:30][CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20]([N:28]([CH2:29][CH2:30][CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:27]2[C:37]([CH3:41])=[CH:38][CH:39]=[CH:40][C:26]=2[CH3:25])=[O:21])[C:9]2[C:10]([CH3:16])=[CH:11][CH:12]=[CH:13][C:14]=2[CH3:15])=[O:7])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 35383Butyric acid, 4-(p-chloro-N-2,6-xylylbenzamido)-HCID 20292063Ethyl 4-(2,6-dimethylanilino)butyrate

生成物 1

HCID 20292087ethyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-(2,6-dimethylanilino)butyrate

実験手順

Analogously to Example 1, using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyric acid and ethyl 4-(2,6-dimethylanilino)butyrate and suitable processing produces ethyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-(2,6-dimethylanilino)butyrate (M.P. 95° to 97°), the saponification of which and the processing of the reaction product yields N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-(2,6-dimethylanilino)butyric acid (M.P. 129° to 131°).

出典と根拠

ORDレコード
ord-5fbd41b6550e43afb086522ffb80b0d0
出典データセット
uspto-grants-1981_02
特許番号
US04250183

関連ノート

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