Water → 2,2'-Isopropylidene bis(4-fluorophenol)

反応式

B(Br)(Br)Br.[F:5][C:6]1[CH:7]=[CH:8][C:9]([OH:24])=[C:10]([C:12]([C:15]2[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=2[O:22]C)([CH3:14])[CH3:13])[CH:11]=1.O>ClCCl>[C:12]([C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[OH:22])([C:10]1[CH:11]=[C:6]([F:5])[CH:7]=[CH:8][C:9]=1[OH:24])([CH3:14])[CH3:13]

参加物

実験手順

Boron tribromide (1 ml) in dichloromethane (10 ml) was added dropwise to a solution of 2-(5-fluoro-2-hydroxyphenyl)-2-(5-fluoro-2-methoxyphenyl)propane (0.5 g) in dichloromethane (10 ml) at -70° C. The solution was stirred at this temperature for one hour and water was then added. The organic layer was separated, dried (Na2SO4) and the solvent removed to give a colourless product which crystallised from hexane to give colourless prisms of 2,2'-isopropylidene bis(4-fluorophenol) (0.375 g); m.p. 155° C.