2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 62412-39-9

HRID 1414238ノート

反応式

HRID 1414238 の反応式
[CH3:1][S:2][C:3]1[O:7][C:6]([C:8]([Cl:10])=[O:9])=[N:5][N:4]=1.[NH2:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[C:14]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[N:13]=1>O1CCOCC1>[ClH:10].[NH2:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[C:14]([N:26]2[CH2:31][CH2:30][N:29]([C:8]([C:6]3[O:7][C:3]([S:2][CH3:1])=[N:4][N:5]=3)=[O:9])[CH2:28][CH2:27]2)[N:13]=1

参加物

4

反応物 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 135447285-(Methylsulfanyl)-1,3,4-oxadiazole-2-carbonyl chloride

生成物 1

HCID 1594277762412-39-9収率 99.2%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

A solution of 5-methylthio-1,3,4-oxadiazole-2-carbonyl chloride (0.601 g., 3.36 mmole) in dioxane (10 ml.) was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (0.972 g., 3.36 mmole) in dioxane (100 ml.). The resultant mixture was stirred at room temperature for 65 hours, then was heated at reflux for 30 minutes. Filtration gave the title compound (1.56 g.). Recrystallization from methanol gave a product having a M.P. of 280°-285° C. with decomposition.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 30 minutes
  3. filtrationFiltration

出典と根拠

ORDレコード
ord-685cc610624c441b8623e6cf12e2104e
出典データセット
uspto-grants-1977_01
特許番号
US04001238

反応ノート

読み込み中…