HCID 4623526、化合物 → 6-(4-Chlorobenzene-1-sulfonyl)pyridin-3-amine

HRID 1414355ノート

反応式

HRID 1414355 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][N:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Ni]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][N:12]=2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 4623526HCID 4623526、化合物

生成物 1

HCID 214870716-(4-Chlorobenzene-1-sulfonyl)pyridin-3-amine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

24.5 g of 2-(4'-chlorophenylsulphonyl)-5-nitro-pyridine is dissolved in 300 ml of ethanol, and the solution, after the addition of 3 g of Raney nickel, hydrogenated at a temperature of between 20°and 35° C until the reaction ceases. Raney nickel is filtered of under nitrogen by suction. The solvent is evaporated off under vacuo to obtain 2-(4'-chlorophenylsulphonyl)-5-amino-pyridine, which is further processed in the crude state.

後処理

  1. customhydrogenated at a temperature of between 20°and 35° C until the reaction ceases
  2. filtrationRaney nickel is filtered of under nitrogen by suction
  3. customThe solvent is evaporated off under vacuo

出典と根拠

ORDレコード
ord-8785a1ca232a4e70ad2b2035ac60ed8b
出典データセット
uspto-grants-1977_01
特許番号
US04001254

反応ノート

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