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4-Toluenesulfonyl chloride → N,N-bis(2-(p-toluenesulfonyloxy)ethyl)-p-toluenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | N,N-Bis(2-hydroxyethyl)-4-methylbenzenesulfonamide | HCID 81565 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N,N-bis(2-(p-toluenesulfonyloxy)ethyl)-p-toluenesulfonamide | HCID 267409 | — |
反応手順
Procedure 3 is illustrated with the preparation of (-)-(RR)-8a' and (+)-(RR)-8b', with (-)-(R)-6f' as a byproduct. In dry pyridine at 0°, N,N-bis-(2-hydroxyethyl)-p-toluenesulfonamide (m.p. 96°-99°) was tosylated with tosyl chloride by the standard method to give N,O,O'-tritosyldiethanolamine, m.p. 85°-87°. [Can. J. Chem. 45, 1555 (1967) gives 78°-79°].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04001279 |
| 出典データセット | uspto-grants-1977_01 |
| ORD ID | ord-0ab10b2563654590921d806eedcd1473 |
| 出典メモ | uspto-grants-1977_01 |