Iodine → 3-Chloro-2,4,5-trimethylbenzophenone

HRID 1414458

反応式

HRID 1414458 の反応式
[CH3:1][C:2]1[CH:15]=[C:14]([CH3:16])[C:13]([CH3:17])=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].II.[Cl:20]Cl>ClC=C(Cl)Cl>[Cl:20][C:15]1[C:2]([CH3:1])=[C:3]([CH:12]=[C:13]([CH3:17])[C:14]=1[CH3:16])[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5]

参加物

5

反応物 3

HCID 807IodineHCID 24526ChlorineHCID 14907151Phenyl(2,4,5-trimethylphenyl)methanone

生成物 1

HCID 214875603-Chloro-2,4,5-trimethylbenzophenone収率 67.2%

試薬・触媒・溶媒 1

HCID 6575Trichloroethylene溶媒

実験手順

33.6 parts of 2,4,5-trimethylbenzophenone and 0.1 part of iodine are dissolved in 150 parts of trichloroethylene. 19.2 parts of chlorine is passed into this solution at 0° to 5°C over a period of 3 hours. The mixture is stirred for another 5 hours at ambient temperature and then distilled at subatmospheric pressure. 26 parts (67.2% of theory) of 3-chloro-2,4,5-trimethylbenzophenone is obtained at 155° to 165°C at 0.1 mmHg.

後処理

  1. distillationdistilled at subatmospheric pressure

出典と根拠

ORDレコード
ord-bc0ba4aad76840a0b3246889284770bc
出典データセット
uspto-grants-1977_01
特許番号
US04001335

関連ノート

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