Potassium Hydroxide → 3-Hydroxy-3-phenylpropanoic acid

HRID 1414753ノート

反応式

HRID 1414753 の反応式
[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[K+]>C(O)C>[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 99818Ethyl 3-phenylhydracrylate, (+-)-

生成物 1

HCID 929593-Hydroxy-3-phenylpropanoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 3-hydroxy-3-phenylpropanoate (19 g, 0.1 mole) was refluxed in a solution of KOH (10 g, 0.2 mole) in ethanol for two hours. The solvent was removed in vacuo and the residue was dissolved in H2O. The H2O solution was extracted with ethyl ether, then acidified with 37% hydrochloric acid. The oily product was extracted out with chloroform and the chloroform was removed in vacuo to yield 10 g (62.5%).

後処理

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in H2O
  3. extractionThe H2O solution was extracted with ethyl ether
  4. extractionThe oily product was extracted out with chloroform
  5. customthe chloroform was removed in vacuo
  6. customto yield 10 g (62.5%)

出典と根拠

ORDレコード
ord-cdcbffa4f09742e9845325766a34354c
出典データセット
uspto-grants-1977_01
特許番号
US04002660

反応ノート

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