Water → 4-Chloro-5-(1-methylhydrazino)-2-phenyl-3(2H)-pyridazinone

HRID 1414873

反応式

HRID 1414873 の反応式
[Cl:1][C:2]1[C:3](=[O:15])[N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1Cl.[CH3:16][NH:17][NH2:18].O>CO>[Cl:1][C:2]1[C:3](=[O:15])[N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:6][C:7]=1[N:17]([CH3:16])[NH2:18]

参加物

5

反応物 3

HCID 962WaterHCID 6061MethylhydrazineHCID 728134,5-Dichloro-2-phenyl-3(2H)-pyridazinone

生成物 1

HCID 3766864-Chloro-5-(1-methylhydrazino)-2-phenyl-3(2H)-pyridazinone

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution consisting of 22.9 grams of 4,5-dichloro-2-phenylpyridazin-3(2H)-one in 120 grams of methanol is added 20 grams of methylhydrazine. The reactants are heated to reflux for two hours, cooled and poured into one kilogram of water. The resulting precipitate is separated by filtration, washed with water and dried. The solid is crystallized from benzene and methanol to yield 4-chloro-2-phenyl-5-(1-methylhydrazino)-pyridazine-3(2H)-one (m.p. 128° to 130° C with decomposition).

後処理

  1. temperatureThe reactants are heated
  2. temperatureto reflux for two hours
  3. temperaturecooled
  4. customThe resulting precipitate is separated by filtration
  5. washwashed with water
  6. customdried
  7. customThe solid is crystallized from benzene and methanol

出典と根拠

ORDレコード
ord-1e39f32ecc734faaa13609b438039ac2
出典データセット
uspto-grants-1977_01
特許番号
US04002751

関連ノート

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