化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Levonorgestrel
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Levonorgestrel EP Impurity B | HCID 29979902 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Levonorgestrel | HCID 13109 | — |
反応手順
Stir 13β-ethyl-17α-ethynyl-17β-hydroxy-gon-5(10)-en-3-one (0.1 g.) with a mixture of methanol (36 cc.), water (1.6 cc.) and concentrated hydrochloric acid (2.4 cc.) for 1 hour. Add water and extract the mixture with ether. Wash, dry and evaporate the ethereal solution and recrystallize the residue from ether-hexane to obtain the title compound, m.p. 203°-6° undepressed on admixture with authentic material. Infrared spectrum 3.05, 3.5, 6.05, 9.4 μ.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04002746 |
| 出典データセット | uspto-grants-1977_01 |
| ORD ID | ord-42832c707e07449bb437a10f30a9d7d3 |
| 出典メモ | uspto-grants-1977_01 |