化工社化工社 化学情報印刷レポート · 研究参考用
Acetaldehyde → Netilmicin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetaldehyde | HCID 177 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Phosphoric Acid | HCID 1004 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Sisomicin | HCID 36119 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Netilmicin | HCID 441306 | — |
反応手順
in the procedure of above Example 1A instead of adding 1 N sulfuric acid to the solution of sisomicin in water until it reaches a pH of about 5, other acids may be used, such as acetic acid, trifluoroacetic acid, p-toluenesulfonic acid, hydrochloric acid, phosphoric acid, or nitric acid. The acidified aqueous solution is then treated with acetaldehyde and sodium cyanoborohydride and the resultant product is purified as described above, whereby is obtained 1-N-ethylsisomicin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04002742 |
| 出典データセット | uspto-grants-1977_01 |
| ORD ID | ord-1cf3e61ee5494d7a91ba96e414aab62f |
| 出典メモ | uspto-grants-1977_01 |