Ethyl orthoformate → 7-chloro-3-ethyl-5-methyl-3H-imidazo[4,5-b]pyridine-6-carboxylic acid, ethyl ester
反応式
[NH2:1][C:2]1[C:3]([Cl:17])=[C:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:5]([CH3:11])=[N:6][C:7]=1[NH:8][CH2:9][CH3:10].[CH2:18](OC(OCC)OCC)C>>[Cl:17][C:3]1[C:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:5]([CH3:11])[N:6]=[C:7]2[N:8]([CH2:9][CH3:10])[CH:18]=[N:1][C:2]=12参加物
3
実験手順
25.7 g. of 5-amino-6-ethylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester (0.1 mol.) is refluxed for 12 hours with 100 ml. of orthoformic acid triethyl ester with stirring. The excess ester is removed in vacuo and the oily residue distilled to obtain 7-chloro-3-ethyl-5-methyl-3H-imidazo[ 4,5-b]pyridine-6-carboxylic acid, ethyl ester, b.p. 195° 0.01. Yield 23 g. (86%).
後処理
- customThe excess ester is removed in vacuo
- distillationthe oily residue distilled
出典と根拠
- ORDレコード
- ord-8ed144ab778a4ded810e32e073fcd8f1
- 出典データセット
- uspto-grants-1977_01
- 特許番号
- US04003908
反応ノート
読み込み中…