6-(1-Butyl)hydrazino-4-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester → 5-Amino-6-butylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester

HRID 1415139ノート

反応式

HRID 1415139 の反応式
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([NH:11]NCC)[N:5]=[C:4]([CH3:15])[C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17].C(O[C:24]([C:26]1C(C)=NC(NNCCCC)=[C:30]([N+]([O-])=O)[C:31]=1Cl)=O)C>>[NH2:8][C:7]1[C:2]([Cl:1])=[C:3]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:4]([CH3:15])=[N:5][C:6]=1[NH:11][CH2:24][CH2:26][CH2:31][CH3:30]

参加物

3

反応物 2

HCID 537780776-(1-Butyl)hydrazino-4-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl esterHCID 867344174-Chloro-6-(1-ethyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester

生成物 1

HCID 123876195-Amino-6-butylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester収率 72%

実験手順

By replacing 4-chloro-6-(1-ethyl)hydrazino-2-methyl-5-nitropyridine-3-carboxylic acid, ethyl ester in Example 1 c with 6-(1-butyl)hydrazino- 4-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester, 5-amino-6-butylamino-4-chloro-2-methylpyridine-3-carboxylic acid, ethyl ester is obtained. Yield 72%, b.p. 200°-210° /0.01.

出典と根拠

ORDレコード
ord-f2834c0aea58482a8acaf1e0c548ce0d
出典データセット
uspto-grants-1977_01
特許番号
US04003908

反応ノート

読み込み中…