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Urea → 2-Ethyl-1-ureidohexylphosphonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | Tris(2-chloroethyl) phosphite | HCID 8783 | — |
| 反応物 | 2-Ethylhexanal | HCID 31241 | — |
| 反応物 | 1-Ureidopropyl-phosphonic acid | HCID 21484022 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Ethyl-1-ureidohexylphosphonic acid | HCID 21484023 | — |
反応手順
This compound is prepared from urea, tris(2-chloroethyl) phosphite, 2-ethylhexaldehyde, and water under conditions similar to those used for the preparation of 1-ureidopropyl-phosphonic acid in Example 4. The product is obtained as a white solid: mp 206° C dec; 31P nmr (CD3SOCD3) -23.2 ppm; 1H nmr δ8.5 (broad, 4, HO and NH2), 6.2 (d, 1, J = 8Hz, NH), 4.3 (d, of d, 1, J = 8 and 20Hz, PCH), 1.3 and 0.9 (m, 15); acidity 2.00 equiv/mole, pK1 = 3.50, pK2 = 9.08.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04003965 |
| 出典データセット | uspto-grants-1977_01 |
| ORD ID | ord-59b4a74bb06e49629d5405ceded3fef5 |
| 出典メモ | uspto-grants-1977_01 |